BioAging® - Prevention of genetic and acquired health risks

• BioAging® stands for the latest scientific founded methodology that has been evaluated to produce software for the purpose of preventative medicine and antiAging diagnostics.
  
• With its variety of specific modules, BioAging® provides the physicain highly effectient software to identify health hazards accurately and economically.
  
• The BioAging® software turns your windows computer into an autonomous examination system which the patient himself can turn for his systemic, medically recognised, preventative and AntAging diagnostics.
  
• The contents of BioAging® is subject to continous supervision by Professor Dr. Alfred Wolf, Germany. 
  

The software provides physicians with well-structured and systemic software for clinical routine in the specialties of preventive medicine, AntiAging medicine and salutogenesis at the highest medical standard. For the classical medical disciplines too, such as general medicine, internal medicine, sports medicine, neurology, gynecology, urology, orthopedics, dermatology and plastic surgery, the BioAging® system is a significant enhancement to diagnostics. Parallel to the systemic measurement of the functional organ vitality and biological aging, the attending physician is now in a position to actually target prevention and screen for risks. Specific and targeted identification of risks Specific screening means that for the respective symptoms, it is easier for the physician to select a pre-setting that has been developed in line with evidence-based guidelines. As a result, the doctor can examine the patient with a high degree of efficiency, at savings to costs and in the interests of prevention; the examination is hence specific to the organs examined and the vitality and laboratory parameter selected by the physician against the background of the latest scientific insights. Cardiovascular disease (heart attack, stroke, arteriosclerosis) Diabetes Type 2 Osteoporosis Dementia Depression Malignant growth (mamma, prostate, colon) Anamnesis (Health history questionnaire) Analysis of lifestyle and patient anamnesis – the digital questionnaire The patient’s anamnesis is comprised of an interactive questionnaire, which can be completed directly at the PC by the patient without the assistance of medical professionals. The anamnesis questionnaire puts questions of relevance to the patient’s health, all of which can be answered by an appropriate click on the respective text contents. The following aspects are covered: Family anamnesis (familial risks and life expectancy) Personal anamnesis in respect of risks such as heart attack, stroke, osteoporosis, diabetes, malignant growth Questions on lifestyle Questions on sports and diet Questions on ailments (based on Heinemann method for men, Menopause rating scale for women) Analysis of sports practiced, detailing the discipline, time input and energy consumption (in Kcal). The answers to the various questions provide the substance of the BioAging® health report (Word document) in which text modules generate a summary assessment. The sentences are simply worded so as to be easily un-derstood. An overview in graph form with green and red bars reflects the biological age of the patient, such as derived from the patient’s responses (i.e. anamnesis and lifestyle).

Diagnostic The computer guided diagnostic module covers all systemic health parameters that reflect the age-related loss of vitality and hence the biological status of aging. The following biomarkers are determined in the system:

State of health / reason for consultation (a questionnaire on current ailments, for men and women separately) Body composition Body Mass Index Waist to hip ratio (women) Waist circumference (men and women) Bioimpediance analysis (body fat percentage, lean body mass and body cell mass) Cerebral function Acoustical reaction Visual reaction Highest audible pitch Memory test with symbols (items) Memory test with figures (abstract)

Landolt index test (concentration/associative memory)

Balance and motor response (balancing test)

Musculature Measurement of handgrip strength, right and left Number of wall prop-ups Number of knee bends Muscle speed Muscular coordination (finger tapping) Flexibility of joints Hands on the ground Hands together behind back Cardiovascular function Blood pressure at rest and after exercise Pulse at rest and after exercise Pulse index Polar Own-Index® VO2 maximum measurement Step test (indirect measurement)

Pulmonary function VC (vital capacity) FVC (forced vital capacity) FEV 1 sec (forced expiratory vital capacity in 1 sec)

BioAging® Laboratory diagnostics Once the test results are available, input of the laboratory data is carried out manually. Most substances are checked for compliance with fixed upper and lower limit values (that can be altered by the physician). Analytes that change in course depending on age are compared to age-related values and analogously allocated a biological age.

Hormone Analysis

FSH (women) LH (men)   Estradiol Estrone   Testosterone Free testosterone   SHBG TSH   DHEAS Cortisol   Progesterone 17 OH-Progesterone   IGF-1 IGFBP-3   Serotonin Melatonin

Biochemical Risk Markers

Arteriosclerosis/CVD Total cholesterol HDL and LDL cholesterol Triglyceride Lipoprotein(a) Homocysteine Fibrinogen   Hs-CRP test PAI 1       Alzheimer ApoE4         Diabetes OGT Insulin 0/60/120 min OGT glucose 0/60/120 min   HOMA index HbA1c test       Malignant growth Total PSA (prostate Ca) Hemocult (FOB test) (Colon Ca)   Tumor marker Ca 12-5 Tumor marker Ca 15-3   Tumor marker CEA         Osteoporosis Ctx (Crosslaps in serum) Osteocalcin   1,25 OH vitamin D3 Calcium (in serum)   Creatinine (in serum)         Oxidation status TOC (Total oxidative capacity) TAC (Total antioxidative capacity)   Malonate dialdehyde (MDA) 8 OH-d Guanosine (urine)       Apparative Risk Diagnosis           Osteoporosis z score t score       Dermatology Skin thickness (pulsed ultrasound)             Malignant growth Transrectal prostate sonography (TRUS)   Mammography (mamma)   Sonography of mamma   Infrared mammography       Cardiovascular disease ECG exercise stress test   Carotid Doppler ultrasound

BioAging® Health report The health report features all the data covered by the BioAging® system in numerical and graph form, in conjunction with a systemic overview of the health status of the respective subject. No recommendations for therapy are given, however, this depending on the individual mode of procedure and specific expertise of the attending physician. Only those tests are shown in the reports that were actually carried out. If you are only using a test as control mechanism, for example, the report will be correspondingly brief. The BioAging® health report takes the form of a Word document (20 - 25 pages). This means you may individualize and enhance the report by including your own remarks, other anamnestic data derived from a personal consultation or other results from additional examinations. The report can be discussed with the patient and then handed over to him/her, since it is easy to read and well structured. The graphs make it easier to appreciate the copious numerical values. Health report - Anamnesis (Health history) This part of the report consists of a simple text, which can also be understood by medical non-professionals. It is compiled from the responses to multiple-choice questions from the health anamnesis questionnaire. For each chapter there is a paragraph specifying the respective biological age. The overview at the end makes it easy for you to identify any divergence.

Health Report - Diagnostics The chapter Diagnostics in the BioAging® report initially gives a brief and general description of measurements and chapter contents. The results are presented numerically (actual value and age-related targeted value) and in graph form with any divergence given as percentage. The color green denotes the performance is better than the gender-specific average age, whereas a red bar signalizes a correspondingly poor result, which is an indication for intervention or prevention. A result in the yellow area points to the need for check-up and is not yet to be classified as a general deficiency. Previous strain, personal exhaustion, stress, a daily structure involving varying degrees of concentration and performance capacity can be the cause of such results that need checking and should be the indication for repeating the respective test after some 4 to 6 weeks, including careful preparation.

Health Report - Laboratory data The input of laboratory data can be protected by an access password. In this case, you need to put in the ceiling values and the units used for the laboratory parameters. The input of the laboratory values is carried out manually. Should there be other parameters for determination, parallel to the wide pre-selection range, there is another section for ´laboratory parameters selected individually by the physician`.

BioAging® Longitudinal comparison For the longitudinal view of the results, all data and sessions can be compared and printed in graph form. It is thus easy to monitor the course of a physical function since the first measurement was taken or since the beginning of therapy. Scientific evidence and studies All reference data in the BioAging® system has been evaluated during the course of complex clinical studies. For each biomarker of the system, there is a representative regression curve with gender-specific and age-related reference values for comparison with the respective measurement taken.

If you have any questions in respect of how to participate please contact Dr Gunn by sending an  email

BioAging® GmbH
Baumreute 32
70199 Stuttgart
Germany

Mailing adress:
Baumreute 32,
70199 Stuttgart , Germany
Telephone (49) 711 66458 10
Facsimile (49) 711 66458 11
E-Mail info@bioaging.de

http://www.bioaging.de/

Managing Director
Florian Wolf